Sublingual Minoxidil for the Treatment of Male and Female Pattern Hair Loss: a randomized, double-blind, placebo-controlled, phase 1B clinical trial

Bokhari, Laita. BSc (Hons), MPhil (Med), Jones, Leslie MSc, PhD, Sinclair, Rodney Daniel. MBBS, MD, FACD1,2 - Sinclair Dermatology

Minoxidil is an approved medication for severe hypertension androgenetic alopecia. Oral minoxidi is a potent vasodilator used to treat hypertension. It is a pro-drug, activated by hepatic dehydroepiandosterone sulfotransferase (SULT2A1) to minoxidil sulfate.

SULT1A1 predicts weak hair regrowth with both ML and OM. Weak hair growth due to low follicular SULT1A1 can be overcome with OM through dose escalation, but cannot be overcome with ML due to low solubility and saturation absorption kinetics.

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